While disease was a constant element of life in The Ancient World forward, several ''outbreaks'' of contagion would be so devastating that they would be remembered even thousands of years later by Researchers. One such of The ancient World was The so-named ''Plague of Athens'' of 430 BC. So destructive, that the contagion killed between 70 and 125,000 peoples. The Plague was seen a responsible for The Athenian loss during The Peloponnesian War. The cause of the contagion has still never been formally identified, but both Typhus and Viral Hemorrhagic Fever have both been advanced as likely (perhaps even combined).
Athens being a major Seaport to The Ancient World was also seen as the most likely starting point. Couple with sub-standard sanitation and poor diet (both added to the excess of a raging War), all played a part in the rapid spread of the contagion. Two such ''outbreaks'' occurred which almost destroyed The City and surrounding Regions population. The outbreaks would last for nearly 2 years. Examinations of mass burial graves show that the contagion completely broke down the body's system very quickly. Most Researchers agree that the ''unknown'' contagion did not re-occur again after 426 BC.